| Main Title |
Thirteen Week Inhalation Toxicity Study of C4/C5 Hydrocarbon Blends in Rats with Cover Letter dated 03/22/85. |
| CORP Author |
American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
25 Mar 1985 |
| Year Published |
1985 |
| Report Number |
FYI-AX-0385-0332-SU; |
| Stock Number |
OTS-0000332-1 |
| Additional Subjects |
Rats ;
Research ;
Environmental health ;
Health hazards ;
Inhalation toxicity ;
Hydrocarbon blends C4/C5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000332-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
178p |
| Abstract |
The inhalation toxicity of 50:50 mixtures of n-butane-n-pentane or isobutene: isopentane was evaluated in two studied conducted simultaneously using common controls. Male and female Fisher 344 rats were exposed to the hydrocarbon mixtures at 4500 ppm and 1000 ppm for 6 hrs per day, 5 days per week for 13 weeks. Chamber atmospheres were monitored by Infrared spectroscopy and gas chromatography. Mean daily concentrations were within (plus or minus)10% of the target values for 99% of all exposure days. Minimal numbers of exposure-related toxic effects were observed in the rats throughout the study. Body weights of the isobutene/isopentane-exposed rats were unaffected relative to those of controls. Inhalation of the n-butane/n-pentane mixtures however produced statistically significant decreases in body weights by Test Weeks 3 and 4 for both sexes, with male rats recovering towards the end of the exposure period. Gross lesions observed at necropsies performed for subgroups of male rats after 4 exposure weeks, and for the remaining male and all female rats after completion of the 13-week period were considered to be spontaneous and unrelated to the exposures. Liver and kidney weights were unaffected by the exposures. The kidneys, submitted to Experimental Pathology Laboratory, Inc. for histopathologic examination, failed to reveal any evidence of hydrocarbon nephropathy in male or female rats from any treatment group. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Category Codes |
57; 68 |
| NTIS Prices |
PC A10/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010001120 |
| Origin |
NTIS |
| Type |
CAT |
