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Main Title Effects of Selected Anti-Tumor-Promoting Chemicals on Metabolic Cooperation between Chinese Hamster V79 Cells.
Author Mills, L. J. ; Nelson, S. M. ; Malcolm, A. R. ;
CORP Author Science Applications International Corp., Narragansett, RI.;Environmental Research Lab., Narragansett, RI.
Publisher c1994
Year Published 1994
Report Number EPA-68-C1-0005; EPA/600/J-94/482 ; ERLN-1434
Stock Number PB95-136867
Additional Subjects Anticarcinogenic agents ; Metabolism ; Gap junctions ; Antitumor drug screening assays ; Biomedical measurement ; Hamsters ; Cells(Biology) ; Biological effects ; Synaptic transmission ; Neural inhibition ; In vivo analysis ; In vitro analysis ; Reprints ; Metabolic cooperation ; V79 Chinese hamster cells
Library Call Number Additional Info Location Last
NTIS  PB95-136867 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Abstract Many tumor-promoting chemicals inhibit gap junctional communication between cells. The authors investigated the possibility that antipromoting chemicals may act inversely and enhance gap junctional communication. The V79/metabolic cooperation assay is an in vitro test that measures gap junctional communication indirectly by determining the extent of metabolic cooperation between mutant and wild-type V79 Chinese hamster lung fibroblasts in culture. Six in vivo antipromotors (caffeine, 3-isobutyl-1-methylxanthine (IBMX), phenidone, dibromoacetophenone, tosylphenylalanine chloromethylketone (TPCK), and acetic acid) were tested in this assay to assess their effects on metabolic cooperation. These results indicate that some antipromoters interfere with the ability of a tumor-promoting chemical to inhibit metabolic cooperation and suggest that alteration of gap junctional communication be a mechansim of antipromoter action.
Supplementary Notes Pub. in Toxicology and Applied Pharmacology 126, p338-344 1994. Sponsored by Environmental Research Lab., Narragansett, RI.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effects of Selected Anti-Tumor-Promoting Chemicals on Metabolic Cooperation between Chinese Hamster V79 Cells.
Category Codes 57Q; 57Y; 57F
NTIS Prices PC A02/MF A01
Primary Description 600/05
Document Type NT
Cataloging Source NTIS/MT
Control Number 500621945
Origin NTIS
Type CAT