| Main Title |
5-Methylhexanoic Acid Developmental Toxicity Testing. |
| Author |
Narotsky., M. G. ;
|
| CORP Author |
ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
Jan 91 |
| Year Published |
1991 |
| Report Number |
EPA-68-02-4450; EPA/600/1-91/001; |
| Stock Number |
PB91-141838 |
| Additional Subjects |
Toxicity ;
Aliphatic acids ;
Valproate ;
Teratogens ;
Rats ;
Dose-response relationships ;
Females ;
Body weight ;
Tables(Data) ;
Reproduction(Biology) ;
Litter size ;
Structure-activity relationship ;
Parturition ;
5-Methylhexanoic acid
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-141838 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
23p |
| Abstract |
As part of an investigation of the developmental effects and structure-activity relationships of aliphatic acids, 5-methylhexanoic acid was administered by gavage to Sprague-Dawley rats on gestation days 6-15 at doses of 0, 300, and 400 mg/kg/day. The dams were allowed to deliver and their litters were examined through postnatal day 6. Pups that were found dead were examined for soft-tissue alterations. On day 6, two survivors per litter were preserved for skeletal examination. Maternal toxicity was demonstrated at both 300 and 400 mg/kg by reduced weight gains, altered respiration (rales, dyspnea) and death. Body weight losses early in the treatment period were also evident at 400 mg/kg. In spite of the marked maternal toxicity present, there were no clear developmental effects; litter size, pre- and postnatal viability, and pup weights were unaffected by treatment. Skeletal examinations of selected pups also revealed no compound effects. |
| Supplementary Notes |
Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| Category Codes |
57Y; 57Q |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
107432797 |
| Origin |
NTIS |
| Type |
CAT |
