| Main Title |
Physiologically-Based Pharmacokinetic Modeling. |
| Author |
Andersen, M. E. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Pharmacokinetics Branch. |
| Publisher |
cJan 94 |
| Year Published |
1994 |
| Report Number |
EPA/600/J-94/319; |
| Stock Number |
PB94-197175 |
| Additional Subjects |
Pharmacokinetics ;
Physiology ;
Biological models ;
Aromatic hydrocarbons ;
Chlorohydrocarbons ;
Metabolism ;
Dose-response relationships ;
Species diversity ;
Risk assessment ;
Retinoids ;
Volatile organic compounds ;
Reprints ;
Physiologically-based pharmacokinetic models
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB94-197175 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Physiologically-based pharmacokinetic (PB-PK) models attempt to provide both a realistic anatomic description of the animal to which a drug or toxic chemical has been administered and a biologically accurate representation of the physiological pathways for chemical storage, metabolism, and elimination in the animal. Because these models explicitly incorporate information about the biological factors which affect chemical disposition, they are particularly useful for high- to low-dose and interspecies extrapolation of pharmacokinetics. The complexity of any particular PB-PK model depends on the chemical studied and the objectives underlying model development. The primary focus of the brief overview is the structure of PB-PK models developed for three specific classes of chemicals: volatile organic compounds (VOCs), dioxin-like chlorinated aromatic hydrocarbons, and retinoids. In addition, the risk assessment objectives underpinning model development and the continuing data needs in refining and extending these models are briefly discussed. (Copyright (c) 1994 Drug Information Association Inc.) |
| Supplementary Notes |
Pub. in Drug Information Jnl., v28 n1 p247-254 Jan 94. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Physiologically-Based Pharmacokinetic Modeling. |
| Category Codes |
57Q; 57S |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
425927269 |
| Origin |
NTIS |
| Type |
CAT |
