| Main Title |
Numerical Methods for the Life Scientist Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB / [electronic resource] : |
| Type |
EBOOK |
| Author |
Prinz, Heino.
|
| Publisher |
Springer Berlin Heidelberg : Imprint: Springer, |
| Year Published |
2011 |
| Call Number |
QH324.2-324.25 |
| ISBN |
9783642208201 |
| Subjects |
Life sciences ;
Bioinformatics
|
| Internet Access |
|
| Collation |
IX, 149p. 61 illus., 52 illus. in color. online resource. |
| Notes |
Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
| Contents Notes |
Preparing the computer -- Binding equilibria -- Binding kinetics -- Least squares fit to experimental data -- Multi-parameter fits -- Comparing the two different approaches. . Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered. |
| Place Published |
Berlin, Heidelberg |
| Corporate Au Added Ent |
SpringerLink (Online service) |
| Host Item Entry |
Springer eBooks |
| PUB Date Free Form |
2011 |
| BIB Level |
m |
| Medium |
computer |
| Content |
text |
| Carrier |
online resource |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20130725213649 |
| Language |
eng |
| Origin |
SPRINGER |
| Type |
EBOOK |
| OCLC Rec Leader |
02616nam a22004335i 45 |
