| Main Title |
Phosphodiesterases as Drug Targets [electronic resource] / |
| Type |
EBOOK |
| Author |
Francis, Sharron H.
|
| Other Authors |
|
| Publisher |
Springer Berlin Heidelberg, |
| Year Published |
2011 |
| Call Number |
RM1-950 |
| ISBN |
9783642179693 |
| Subjects |
Medicine ;
Toxicology ;
Biochemistry ;
Enzymes ;
Post-translational modification of proteins ;
Cytology
|
| Internet Access |
|
| Collation |
XVIII, 522 p. online resource. |
| Notes |
Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
| Contents Notes |
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors. |
| Place Published |
Berlin, Heidelberg |
| Corporate Au Added Ent |
SpringerLink (Online service) |
| Title Ser Add Ent |
Handbook of Experimental Pharmacology, 204 |
| Host Item Entry |
Springer eBooks |
| PUB Date Free Form |
2011 |
| Series Title Untraced |
Handbook of Experimental Pharmacology, 204 |
| BIB Level |
m |
| Medium |
computer |
| Content |
text |
| Carrier |
online resource |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20131026205820 |
| Language |
eng |
| Origin |
SPRINGER |
| Type |
EBOOK |
| OCLC Rec Leader |
02440nam a22005415i 45 |
