| Main Title |
Pharmacologic and Immunologic Approaches to the Problems of Posttraumatic Glial Proliferation Following CNS (Central Nervous System) Damage. |
| Author |
Billingsley, M. L. ;
O'Callaghan, J. P. ;
Balaban, C. D. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Milton S. Hershey Medical Center, Hershey, PA. |
| Year Published |
1986 |
| Report Number |
EPA/600/D-86/014; |
| Stock Number |
PB86-148483 |
| Additional Subjects |
Central nervous system ;
Trauma ;
Pharmacology ;
Immunology ;
Deoxyribonucleic acids ;
Biochemistry ;
Histology ;
Rats ;
Laboratory animals ;
Glial cells ;
Thymidine
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-148483 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
33p |
| Abstract |
The authors have devised a pharmacologic approach to block the proliferation of glial cells (gliosis) which follows various forms of trauma to nervous tissue. A method was devised using the incorporation of 3H-thymidine incorporation into DNA of glial cells as a proliferative index following mechanical trauma. Both biochemical and histologic analysis revealed that treatment of lesioned rats with cell-cycle specific antimitotic agents such as cytosine arabinoside reduced glial proliferation as measured by both DNA synthesis and morphologic quantitation of cell numbers around the lesion. Treatment with cytosine arabinoside resulted in the appearance of numerous unusual cells near the lesion, with indications of aborted mitotic spindles in many of these cells. Other antimitotic drugs such as cyclophosphamide and vincristine were also able to inhibit glial proliferation. Additional experiments suggested that immunosuppression prior to lesioning greatly reduced the proliferative response of glial cells. |
| Supplementary Notes |
Prepared in cooperation with Milton S. Hershey Medical Center, Hershey, PA. |
| PUB Date Free Form |
Jan 86 |
| Category Codes |
6O; 6E; 57Q; 57J |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
610119530 |
| Origin |
NTIS |
| Type |
CAT |
