| Main Title |
Metabolism and DNA Adduct Formation of 2-Acetylaminofluorene by Bladder Explants from Human, Dog, Monkey, Hamster and Rat. |
| Author |
Schut, H. A. J. ;
Daniel, F. B. ;
Schenck, K. M. ;
Loeb, T. R. ;
Stoner, G. D. ;
|
| CORP Author |
Medical Coll. of Ohio at Toledo.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/164; |
| Stock Number |
PB85-146801 |
| Additional Subjects |
Environmental surveys ;
Biochemistry ;
Malignant neoplasms ;
Toxicology ;
Metabolism ;
Deoxyribonucleic acids ;
Bladders ;
Amines ;
Laboratory animals ;
Dogs ;
Monkeys ;
Rats ;
Aromatic compounds ;
Industrial hygiene ;
Chemical bonds ;
Reprints ;
Cancer ;
Occupational safety and health ;
Fluorene/acetyl-amino
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-146801 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
It is concluded that bladder explants of the human, dog, monkey, hamster, and rat metabolize AAF mainly to ring-hydroxylated products, but also form small amounts of the proximate carcinogenic metabolite N-hydroxy-AAF. Neither the overall binding of AAF to bladder DNA, nor the formation of specific AAF-DNA adducts is correlated with the relative susceptibilities of these five species to aromatic amine-induced urinary bladder carcinogenesis. |
| Availability Notes |
Pub. in Carcinogenesis, v5 n10 p1287-1292 1984. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Metabolism and DNA Adduct Formation of 2-Acetylaminofluorene by Bladder Explants from Human, Dog, Monkey, Hamster and Rat. |
| PUB Date Free Form |
c1984 |
| Category Codes |
6A; 6T; 7D; 68G; 57B; 57Y; 99F; 41I; 94D |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
510224080 |
| Origin |
NTIS |
| Type |
CAT |
