| Main Title |
Metabolic Alterations in the Squirrel Monkey Induced by DDT Administration and Ascorbic Acid Deficiency. |
| Author |
Chadwick, R. W. ;
Cranmer, M. F. ;
Peoples., A. J. ;
|
| CORP Author |
Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab. |
| Year Published |
1971 |
| Stock Number |
PB-278 098 |
| Additional Subjects |
Toxicology ;
Pesticides ;
Insecticides ;
DDT ;
Ascorbic acid ;
Enzymes ;
Metabolism ;
Biochemistry ;
Nutrition ;
Detoxification ;
Toxic tolerances ;
Nutritional deficiencies ;
Monkeys ;
Laboratory animals ;
Bioassay ;
Dosage ;
Dose rate ;
Reprints ;
Glucuronic acid ;
Glucaric acid ;
Toxic substances
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-278 098 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
A daily po injection of 5 mg of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) given to squirrel monkeys for a 2-wk period produces significant increases in liver weight, microsomal protein, cytochrome P-450 and the in vitro activity of various drug metabolizing enzymes. The results indicate that ascorbic acid deficiency may significantly impair both the induction of O-demethylase and the stimulation of the glucuronic acid system by DDT. The D-glucuronic/D-glucaric acid excretion ratio is significantly depressed within 2 days in monkeys fed the ascorbic acid deficient diet. In addition to ascorbic acid deficiency an unknown nutritional factor from the administration of a second lot of the ascorbic acid deficient diet also appears to cause an inhibition of the D-glucuronic/D-glucaric acid excretion ratio. This study provides evidence that interactions between nutritional status and toxic stress may significantly affect some routes of detoxification in the squirrel monkey. |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology, v20 n3 p308-318, Nov 71. |
| Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 2, PB-278 094. |
| Title Annotations |
Reprint: Metabolic Alterations in the Squirrel Monkey Induced by DDT Administration and Ascorbic Acid Deficiency, |
| PUB Date Free Form |
11 Jan 71 |
| Category Codes |
6T; 6A; 57Y; 68E; 68G; 57B |
| NTIS Prices |
(Order as PB-278 094, MF A01) |
| Primary Description |
500/01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323735909 |
| Origin |
NTIS |
| Type |
CAT |
