| Main Title |
Lysosomes [electronic resource] / |
| Type |
EBOOK |
| Author |
Saftig, Paul.
|
| Publisher |
Springer US, |
| Year Published |
2005 |
| Call Number |
QH573-671 |
| ISBN |
9780387289571 |
| Subjects |
Life sciences ;
Human genetics ;
Neurosciences ;
Biochemistry ;
Cytology
|
| Internet Access |
|
| Collation |
XII, 197 p. online resource. |
| Notes |
Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
| Contents Notes |
History and Morphology of the Lysosome -- Transport of Lysosomal Enzymes -- Adaptor Proteins in Lysosomal Biogenesis -- Lysosomal Membrane Proteins -- Lysosomal Proteases -- Lysosomal Storage Disorders -- Lysosomal Transporters and Associated Diseases -- Neuronal Ceroid-Lipofuscinoses -- Cholesterol Transport in Lysosomes -- Therapy of Lysosomal Storage Diseases -- Lysosomal Proteome and Transcriptome -- External Lysosomes -- Membrane Resealing Mediated by Lysosomal Exocytosis -- Macroautophagy in Mammalian Cells -- Chaperone-Mediated Autophagy. Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment. This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy. This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing. |
| Place Published |
Boston, MA |
| Corporate Au Added Ent |
SpringerLink (Online service) |
| Title Ser Add Ent |
Medical Intelligence Unit |
| Host Item Entry |
Springer eBooks |
| PUB Date Free Form |
2005 |
| Series Title Untraced |
Medical Intelligence Unit |
| BIB Level |
m |
| Medium |
computer |
| Content |
text |
| Carrier |
online resource |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20131218192926 |
| Language |
eng |
| Origin |
SPRINGER |
| Type |
EBOOK |
| OCLC Rec Leader |
03083nam a22004935i 45 |
