| Main Title |
Anal Leakage of 35 Cst. Polydimethylsiloxane Fluid as Affected by Various Additives in the Diet of Rats, with Cover Letter dated 05/09/94. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
86940001000 |
| Stock Number |
OTS0557409 |
| Additional Subjects |
Toxicology ;
Health effects ;
Siloxanes and Silicones ;
Di-me (63148-62-9) ;
Biochemistry ;
Mammals ;
Rats ;
Oral ;
Diet ;
Toxic substances ;
Laboratory animals ;
CAS No 63148-62-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0557409 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
23p |
| Abstract |
This study evaluated the efficacy of the addition of several food additives at preventing anal leakage following the administration of polydimethylsiloxane fluid, 35 cs. (PDMS). Nineteen groups of 5 male rats were administered 105 g PDMS fluid (7%) either alone (control group) or with the addition of 1, 3, 7, 15, or 30 g MS-75, 15 g titanium oxide, 15 g calcium carbonate, 30 g silica, 15 g polydextrose, 30 g stearic acid, 30 g suet, 30 g Solka Floc (BW-200 FCC or BW-300 FCC), 30 g barley bran, Methocel A4M solid or solution, Methocel K15M solution, or Methocel K4M solution in the diet for 7 days. All animals were observed daily for food consumption, anal leakage, stool consistency, and changes in hair coat. Body weights were recorded prior to study initiation and on days 3 and 7. None of the additives affected food consumption or body weight gain compared to the PDMS controls. MS-75 (30 g), stearic acid, suet, and barley bran prevented anal leakage and fecal changes observed in the other treated groups. All other groups were found to have slight to excessive anal leakage and oily feces at some or all intervals during consumption of the PDMS treated diet. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803780 |
| Origin |
NTIS |
| Type |
CAT |
