| Main Title |
Non-Regulated Study: Immune Effects of Oral Exposure of Human Volunteers to Octamethylcyclotetrasiloxane (D4), with Cover Letter dated 12/04/1998. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1998 |
| Stock Number |
OTS0573865 |
| Additional Subjects |
Toxicology ;
Health effects ;
Octamethylcyclotetrasiloxane ;
Biochemistry ;
Mammals ;
Humans ;
Oral ;
Diet ;
CAS No 556-67-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0573865 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
102p |
| Abstract |
Humans are exposed to many commercial and consumer products that contain siloxanes. We investigated the immunological effects of a two-week oral exposure to octamethyicyclotetrasiloxane (Da). Normal volunteers ingested either 12 mg of 04 in com oil or corn oil alone in a double-blind, placebo-controlled, crossover study design. Immunological assays were chosen to screen for an immunotoxic or adjuvant effect. Assays for immunatoxicity included enumeration of peripheral lymphocyte subsets and functional assays using peripheral blood mononuclear cells. Because in humans there is no direct test for adjuvant effect of siloxane exposure, we analyzed pro-inflammatory cytokines and acute phase reactants in peripheral blood as surrogate markers for adjuvancy. Blood was obtained prior to exposure, and after 7 and 14 days of exposure. In these controlled human exposures, no immunotoxic or pro-inflammatonfladjuvant effect of D4 ingestion was found. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
10 Dec 1998 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A07/MF A07 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028701250 |
| Origin |
NTIS |
| Type |
CAT |
