| Main Title |
Methemoglobin Levels in Beagle Dogs Following Oral Administration of P-phenylenediamine. |
| CORP Author |
Clairol Research Laboratories.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8036147 |
| Stock Number |
OTS0506089 |
| Additional Subjects |
Toxicology ;
Health effects ;
P-phenylenediamine ;
Biochemistry ;
Mammals ;
Dogs ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 106-50-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0506089 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
Para-Phenylenediamine (CAS No. 106-50-3) was evaluated as cause for methemoglobinuria in sets of 2 each beagle dogs fed single gavage doses of 1.0, 3.0 and 10.0 mg/kg bodyweight. All dogs exhibited lacrimation, while 10.0 mg/kg dosed dogs showed red and swollen eyes persisting in one dog at 24-hour post-gavage observation. Slight redness was also noted in the eyes of 3.0 mg/kg dogs, but all such signs were resolved by 24 hours after treatment. Cyanosis and anoxia were not noted in any dog of any treatment level. Likewise, methemoglobinemia was not induced at levels producing pharmacotoxic effects in beagle dogs. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801150 |
| Origin |
NTIS |
| Type |
CAT |
