| Main Title |
Cellular and Biochemical Changes in the Lower Airways of Subjects Exposed to Ozone. |
| Author |
Koren, H. S. ;
Devlin, R. B. ;
Graham, D. E. ;
Mann, R. ;
Horstman, D. H. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. School of Medicine. |
| Year Published |
1988 |
| Report Number |
EPA/600/D-88/031; |
| Stock Number |
PB88-170048 |
| Additional Subjects |
Respiratory system ;
Ozone ;
Air pollution ;
Pathophysiology ;
Exposure ;
Inflammation ;
Cell morphology ;
Biochemistry ;
Air pollution effects(Humans)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-170048 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
29p |
| Abstract |
Although exposure of animals to ozone (O3) has been shown to impair host defense mechanisms and to induce inflammation, very little is known about its inflammatory effects in humans. In the study, 11 healthy males, age 18-35, were exposed to 0.4 ppm O3 or filtered air for two hours with intermittent exercise. Eighteen hours later, bronchoalveolar lavage (BAL) was performed. There was an 8.2-fold increase in the number of polymorphonuclear leukocytes (PMNs), and a corresponding decrease in the number of macrophages, indicative of an inflammatory response. No significant change in the number of lymphocytes was observed. A two-fold increase in the levels of classical indicators of vascular permeability (protein and albumin) clearly indicated that an acute O3 exposure can increase permeability. A selected number of biochemical markers known to be associated with inflammation were examined. The results of the study show that an acute exposure to O3 can result in increased levels of inflammatory materials capable of producing pathophysiological changes in the lower airways of humans. |
| Supplementary Notes |
Prepared in cooperation with North Carolina Univ. at Chapel Hill. School of Medicine. |
| PUB Date Free Form |
Feb 88 |
| Category Codes |
57O; 57Y; 68A; 68G |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
811327097 |
| Origin |
NTIS |
| Type |
CAT |
