| Main Title |
Serum Organochlorine Pesticides in Mentally Retarded Patients on Differing Drug Regimens. |
| Author |
Watson, Michael ;
Gabica, Joe ;
Benson., W. W. ;
|
| CORP Author |
Idaho State Dept. of Health, Boise. |
| Year Published |
1971 |
| Stock Number |
PB-279 747 |
| Additional Subjects |
Pesticides ;
DDT ;
Toxicology ;
Tranquilizer drugs ;
Anticonvulsants ;
Patients ;
Gas chromatography ;
Drug therapy ;
Chlorine organic compounds ;
Tables(Data) ;
Experimental data ;
Drugs ;
Metabolism ;
Pharmacology ;
Blood chemical analysis ;
Chemotherapy ;
Reprints ;
Mentally retarded persons ;
DDE insecticide ;
Metabolites ;
Toxic substances ;
Bioaccumulation
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-279 747 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Serum concentrations of p,p'DDT and its metabolite p,p'DDE were estimated by electron-capture gas chromatography in a group of mentally retarded institutionalized patients receiving antiseizure and tranquilizing chemotherapy. Control patients not taking drugs tended to resemble the general population in terms of organochlorine residues, but drug takers showed greatly lowered levels of both p,p'DDE and p,p'DDT. The combination of phenobarbital and diphenylhydantoin seemed to be the most effective in depressing serum pesticides and remained so even in patients taking other drugs concurrently. P,P'DDE was found at detectable levels in all patients sampled, but the frequency of occurrence of p,p'DDT was considerably decreased among the drug takers. This was particularly true of patients receiving both phenobarbital and diphenylhydantoin concurrently. The possibility that the catabolism of p,p'DDT is induced preferentially to that of p,p'DDE by the phenobarbital-diphenylhydantoin combination is discussed. |
| Supplementary Notes |
Pub. in Clinical Pharmacology and Therapeutics, v13 n2 p186-192, Mar-Apr 72. |
| Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 8, PB-279 739. |
| Title Annotations |
Reprint: Serum Organochlorine Pesticides in Mentally Retarded Patients on Differing Drug Regimens, |
| PUB Date Free Form |
22 Nov 71 |
| Category Codes |
6T; 6O; 57Y; 57Q; 68G; 68E |
| NTIS Prices |
(Order as PB-279 739, MF A01) |
| Primary Description |
500/01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323739139 |
| Origin |
NTIS |
| Type |
CAT |
