| Main Title |
Reciprocal Relationship Between the Induction of delta-Aminolevulinic Acid Synthetase and Drug Metabolism Produced by m-Dichlorobenzene. |
| Author |
Poland, Alan ;
Goldstein, Joyce ;
Hickman, Patricia ;
Burse., Virlyn W. ;
|
| CORP Author |
Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Program. |
| Year Published |
1970 |
| Stock Number |
PB-279 736 |
| Additional Subjects |
Drugs ;
Enzymes ;
Liver ;
Dosage ;
Metabolism ;
Pharmacology ;
Chlorine organic compounds ;
Amino acids ;
Porphyrins ;
Nitrogen compounds ;
Experimental data ;
Rats ;
Laboratory animals ;
Physiological effects ;
Tables(Data) ;
Reprints ;
Benzene/dichloro ;
Synthetase/aminolevinate
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-279 736 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
The daily administration of large doses of m-dichlorobenzene (m-DCB) causes experimental hepatic porphyria in rats by induction of delta-aminolevulinic acid synthetase (ALA synthetase). However, smaller doses of m-DCB produce a biphasic stimulation of both urinary coproporphyrin excreation and liver ALA synthetase. The decline of ALA synthetase and urinary coproporphyrin despite continued daily dosage is associated with an increase in activity of the liver drug-metabolizing systems and decreasing serum m-DCB levels. The most probable explanation for the self-limiting action of m-DCB is stimulation by the drug of its own metabolism. |
| Supplementary Notes |
Pub. in Biochemical Pharmacology, v20 p1281-1290 1971. |
| Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 6, PB-279 730. |
| Title Annotations |
Reprint: A Reciprocal Relationship Between the Induction of delta-Aminolevulinic Acid Synthetase and Drug Metabolism Produced by m-Dichlorobenzene, |
| PUB Date Free Form |
26 Jun 70 |
| Category Codes |
6O; 6T; 57Y; 57Q |
| NTIS Prices |
(Order as PB-279 730, MF A01) |
| Primary Description |
500/01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323739022 |
| Origin |
NTIS |
| Type |
CAT |
