| Main Title |
MDI: Study of Absorption after Single Dermal and Intradermal Administration in Rats, with Cover Letter dated 08/11/1999. |
| CORP Author |
International Isocyanate Inst., Parsippany, NJ.; BASF A.G., Ludwigshafen am Rhein (Germany, F.R.). Aktiengesellschaft labor fuer Umweltanalytik und Okologie.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1999 |
| Stock Number |
OTS0573900 |
| Additional Subjects |
Toxicology ;
Health effects ;
Benzene 1 ;
1'-methylenebis(4-isocyanato) ;
Pharmaco kinetics ;
Mammals ;
Rats ;
Dermal ;
Parenteral ;
Intraperitoneal ;
CAS No 101-68-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0573900 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
48p |
| Abstract |
The absorption, distribution and excretion of radioactivity was studied in groups of four male Wistar rats following a single dermal and intradermal administration of 19 Methylenebisphenylisocyanate ('C-MDI) at naminal dose levels of 4.0 and 0.4 mg/cm for dernal administration and 0.4 mg/animal for intradermal administration. These dose levels nomina:11y corresponded to 40 and 4.0 mg/animal for dermal administration. Considering the animal weights, dose levels corresponded to about 140 and 14 mg/kg body weight (dermal administration) and 1.4 mg/kg body weight (intradermal administration). In the experiments with dermal administration, animals were exposed for 8 hours and sacrificed 8, 24 or 120 h after beginning of exposure. In the experiment with intradermal administration, animals were sacrificed 120 h after treatment. After dermal administration of 'C-MDI, mean recoveries of radioactivity from all dose groups were in the range from 97.86 to 108.07 % of the total radioactivity administered. Generally, the largest proportion of.radioactivity was found at the application site and dressing. The total amount of radioactivity absorbed (including excreta, cage wash, tissues/organs and carcass) increased with increasing sacrifice time. Dermal absorption was very low and quantitatively similar at both dose levels; maximally ca. 0.9 % of the applied radioactivity was absorbed. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
16 Aug 1999 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028702020 |
| Origin |
NTIS |
| Type |
CAT |
