| Main Title |
Comparison of In vivo and In vitro Methods for Assessing the Effects of Repeated Dosing with Carbon Tetrachloride on the Hepatic Drug-Metabolizing Enzyme System (Journal Version). |
| Author |
Chadwick, R. W. ;
Copeland, M. F. ;
Carlson, G. P. ;
Trela, B. A. ;
Most, B. M. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Purdue Univ., Lafayette, IN. Dept. of Pharmacology and Toxicology. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/264; |
| Stock Number |
PB89-143705 |
| Additional Subjects |
Transferases ;
Bioassay ;
Carbon tetrachloride ;
Toxicology ;
Hazardous materials ;
In vivo analysis ;
In vitro analysis ;
Rats ;
Chlorobenzenes ;
Liver ;
Experimental design ;
Metabolism ;
Reprints ;
Enzyme repression ;
Enzyme tests ;
Glutathione transferases ;
Comparative evaluations ;
Lindane ;
Toxic substances ;
UDP glucaronyltransferase ;
Sulfurtransferases ;
Benzene hexachloride ;
Dose-response relationships
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-143705 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
The effect of a single i.p. injection of 0, 20, 200, and 1000 microliters/kg carbon tetrachloride on the activity of the hepatic drug-metabolizing enzyme system was measured in the rat by a model substrate assay, employing lindane (gamma-hexachlorocyclohexane), and by a battery of in vitro enzyme assays. The data in the study indicated that carbon tetrachloride had a biphasic influence on the phase I reactions with the lowest dose inducing a significant increase in enzyme activity while the highest dose produced significant inhibition. Significant CCl4-induced reductions in glucaronyltransferase and sulfotransferase activities were also observed while the effect on glutathione-S-transferase was ambiguous. The in vivo and in vitro assays showed good agreement. (Copyright (c) 1988 Elsevier Science Publishers B.V.) |
| Supplementary Notes |
Pub. in Toxicology Letters, v44 p201-213 1988. Prepared in cooperation with Purdue Univ., Lafayette, IN. Dept. of Pharmacology and Toxicology, and Northrop Services, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Comparison of In vivo and In vitro Methods for Assessing the Effects of Repeated Dosing with Carbon Tetrachloride on the Hepatic Drug-Metabolizing Enzyme System (Journal Version). |
| Category Codes |
57Y; 57E; 57B |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
908927497 |
| Origin |
NTIS |
| Type |
CAT |
