| Main Title |
Investigation of the metabolism of chlorinated hydrocarbons in subhuman species / |
| Author |
Smith, C. C. ;
Cragg, S. T. ;
Wolfe, G. F. ;
Weigel, W. W.
|
| Other Authors |
|
| CORP Author |
Cincinnati Univ., OH. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, |
| Year Published |
1985 |
| Report Number |
EPA-600/1-85-001; EPA-R-803963 |
| Stock Number |
PB85-152387 |
| OCLC Number |
58675300 |
| Subjects |
Drinking water--Contamination--United States ;
Chlorine--Physiological effect
|
| Additional Subjects |
Potable water ;
Metabolism ;
Chlorine organic compounds ;
Research projects ;
Toxicity ;
Laboratory animals ;
Dosage ;
Benzene/trichloro ;
Methane/bromo-dichloro ;
Ether/bis(chloroisopropyl) ;
Ether/bis(chloroethyl) ;
Pharmacokinetics
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| ELBD |
EPA 600-1-85-001 |
|
AWBERC Library/Cincinnati,OH |
03/31/2005 |
| NTIS |
PB85-152387 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
xiii, 119 p. : ill. ; 28 cm. |
| Abstract |
The purpose of this research program was to provide metabolic data on four rather common drinking water contaminants. The compounds were 1,2,4-trichlorobenzene (TCB), bromodichloromethane (BDC), bis(2-chloroisopropyl) ether (BCIE) and bis(2-chloroethyl) ether (BCEE). The compounds, labeled with 14C, were administered orally and sometimes intravenously, to rats and rhesus monkeys. Studies on TCB included excretion and tissue distribution in rats, pharmacokinetic studies in monkeys and subchronic studies in monkeys. Daily oral doses of 174 mg/kg were uniformly fatal to monkeys in less than one month. Activity of liver enzymes was increased. Pharmacokinetics and tissue distribution of BDC was examined in rats and monkeys. The compound was excreted primarily via the lung either unchanged or as CO2. BCIE in monkeys was also excreted via the lung and was very toxic to the eyes and kidneys following multiple 30 mg/kg oral doses. Preliminary studies of BCEE in two rhesus monkeys produced the same signs of periorbital toxicity as BCIE when oral doses of 10 mg/kg were administered. |
| Notes |
"PB85-152387." "Grant #R-803963." "Project Officer, Robert Lingg." "January 1985." "EPA-600/1-85-001." |
| Place Published |
Research Triangle Park, NC |
| Corporate Au Added Ent |
Health Effects Research Laboratory (Research Triangle Park, N.C.) |
| PUB Date Free Form |
1985. |
| NTIS Prices |
PC A07/MF A01 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20050329120940 |
| Language |
eng |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
01163nam 2200325Ka 45020 |
