|DNA Adduct Formation by 7,12-Dimethylbenz(a)anthracene and its Noncarcinogenic 2-Fluoro Analogue in female Sprague-Dawley Rats.
Daniel, F. B. ;
Joyce, N. J. ;
|Health Effects Research Lab., Cincinnati, OH.
Deoxyribonucleic acids ;
Laboratory animals ;
Polycyclic aromatic hydrocarbons ;
|Some EPA libraries have a fiche copy filed under the call number shown.
|The potent polycyclic aromatic hydrocarbon 7.2 dimethylbenz(a)anthracene (DMBA) bound to the DNA of numerous organs of the female outbred Sprague-Dawley rat after iv administration under a regimen known to produce a high yield of mammary adenocarcinomas. The maximum DNA binding levels observed following iv administration of 5 mg DMBA range from approximately 12 micromol hydrocarbon/mol deoxyribonucleic for the liver to approximately 5 micromol hydrocarbon/mol deoxyribonucleotide for the mammary gland, the target tissue.
|Pub. in JNCI, v70 n1 p111-118 Jan 83.
|NTIS Title Notes
|Journal article Aug 80-Nov 83.
|Reprint: DNA Adduct Formation by 7,12-Dimethylbenz(a)anthracene and its Noncarcinogenic 2-Fluoro Analogue in female Sprague-Dawley Rats.
|PUB Date Free Form
|13 Aug 82
|6T; 6E; 57Y; 57O
|PC A02/MF A01