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RECORD NUMBER: 2 OF 3| Main Title | Mutagenicity of Cyclopenta-Fused Isomers of Benz(a)anthracene in Bacterial and Rodent Cells and Identification of the Major Rat Liver Microsomal Metabolites. | |||||||||||
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| Author | Nesnow, S. ; Leavitt, S. ; Easterling, R. ; Watts, R. ; Toney, S. H. ; | |||||||||||
| CORP Author | Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
| Year Published | 1984 | |||||||||||
| Report Number | EPA/600/J-84/260; | |||||||||||
| Stock Number | PB85-193969 | |||||||||||
| Additional Subjects | Mutagens ; Bacteria ; Metabolism ; Bioassays ; Aromatic polycyclic hydrocarbons ; Environmental surveys ; Laboratory animals ; Rats ; Liver ; Toxicity ; Public health ; Exhaust emissions ; Chemical analysis ; Molecular structure ; Reprints ; Benzaceanthrylene ; Benzacephenanthrylene | |||||||||||
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| Collation | 14p | |||||||||||
| Abstract | The microsomal metabolites and mutagenic activity of four cyclopenta-fused benz(a)anthracenes; benz(j)aceanthrylene (B(j)A), benz(e)aceanthrylene (B(e)A), benz(l)aceanthrylene (B(l)A) and benz(k)acephenanthrylene (B(k)A) have been studied. Arocolor-1254 induced rat liver microsomes metabolized B(j)A to: B(j)A-1,2-dihydrodiol, B(j)A-9,10-dihydrodiol, B(j)A-11,12-dihydrodiol and 10-hydroxy-B(j)A; B(e)A to: B(e)A-1,2-dihydrodiol, B(e)A-3,4-dihydrodiol, and B(e)A-5,6-dihydrodial; B(l)A to: B(l)A-1,2-dihydrodiol, B(l)A-4,5-dihydrodiol and B(l)A-7,8-dihydrodiol; and B(k)A to B(k)A-4,5-dihydrodiol and B(k)A-89-dihydrodiol. With each PAH, metabolism occurred on the cyclopentaring. All four isomers were active as gene mutagens in S. typhimurium and in Chinese hamster V79 cells. In the S. typhimurium mutation studies using Aroclor-1254 induced rat liver S9, B(j)A, B(e)A, and B(l)A required significantly less microsomal protein for maximal mutation response than B(k)A and B(a)P suggesting a one-step activation mechanism, presumably on the cyclopenta-fused ring. B(j)A, B(e)A, and B(l)A were significantly more mutagenic than B(k)A and B(a)P in S. typhimurium. | |||||||||||
| Supplementary Notes | Pub. in Cancer Research 44, p4993-5003 Nov 84. | |||||||||||
| NTIS Title Notes | Journal article. | |||||||||||
| Title Annotations | Reprint: Mutagenicity of Cyclopenta-Fused Isomers of Benz(a)anthracene in Bacterial and Rodent Cells and Identification of the Major Rat Liver Microsomal Metabolites. | |||||||||||
| PUB Date Free Form | Nov 84 | |||||||||||
| Category Codes | 6T; 6E; 6A; 7D; 68G; 57U; 57B; 57Y; 99A; 99F | |||||||||||
| NTIS Prices | PC A02/MF A01 | |||||||||||
| Primary Description | 600/11 | |||||||||||
| Document Type | NT | |||||||||||
| Cataloging Source | NTIS/MT | |||||||||||
| Control Number | 518921276 | |||||||||||
| Origin | NTIS | |||||||||||
| Type | CAT |