| Main Title |
Teratogenic Effects of the Fungicide Benomyl on Posterior Segmental Regeneration in the Earthworm, 'Eisenia fetida'. |
| Author |
Zoran, M. J. ;
Heppner, T. J. ;
Drewes, C. D. ;
|
| CORP Author |
Iowa State Univ., Ames.;Corvallis Environmental Research Lab., OR. |
| Year Published |
1986 |
| Report Number |
EPA-R-810006; EPA/600/J-86/411; |
| Stock Number |
PB88-104310 |
| Additional Subjects |
Worms ;
Fungicides ;
Regeneration(Physiology) ;
Toxicology ;
Morphology ;
Abnormalities ;
Reprints ;
Teratogenesis ;
Benomyl
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-104310 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
Earthworms, Eisenia fetida, were treated by surface exposure to the fungicide benomyl at various stages of posterior segmental regeneration. Teratogenic effects of benomyl were observed when worms were treated 7-11 days after amputation (i.e. during the normal period of segmental replication), but not during days 1-5, 13-17, or 19-23. Teratogenic effects included a reduction in the number of regenerated segments, an increased frequency of segmental groove anomalies, and a variety of monstrosities. The effects of benomyl treatment on the number of regenerated segments and frequency of anomalies were dose-dependent within a narrow concentration range (approximately 0.2-5.0 mg liter-1); at higher concentrations (e.g. 25 mg liter-1) teratogenic effects were less frequent because the onset of segmental delineation was delayed until well after exposure. Non-invasive electrophysiological recordings from treated worms indicated that functional integrity of giant nerve fiber conduction pathways was established in all anomalously regenerated tail segments, except in a two-tailed monstrosity. The evidence supports the hypothesis that these teratogenic effects derive from an antimitotic mode of action of benomyl on segmental regeneration. (Copyright (c) 1986 Pesticide Science.) |
| Supplementary Notes |
Pub. in Pesticide Science, v17 p641-652 Nov 86. Sponsored by Corvallis Environmental Research Lab., OR. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Teratogenic Effects of the Fungicide Benomyl on Posterior Segmental Regeneration in the Earthworm, 'Eisenia fetida'. |
| PUB Date Free Form |
c1986 |
| Category Codes |
57Y; 57Z; 57H; 68G |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
733832073 |
| Origin |
NTIS |
| Type |
CAT |
