||Effect of Ozone on Drug-Induced Sleeping Time in Mice Pretreated with Mixed-Function Oxidase Inducers and Inhibitors.
Graham, Judith A. ;
Menzel, Daniel B. ;
Miller, Frederick J. ;
Illing, Joseph W. ;
Gardner, Donald E. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Studies were conducted to investigate the effect of ozone in prolonging pentobarbital (PEN)-induced sleeping time (S.T.). Since ozone is a common air pollutant, an ozone-induced alteration of mechanisms of drug action could have public health implications. It was shown that a 5-hr exposure to 1960 micrograms ozone/cu. m. (1 ppm) caused an increased PEN-induced S.T. in female mice (three strains), rats, and hamsters. This response was not observed in male rats or in male mice even when the latter were exposed for 5 hr/day for 3 days. Male hamsters were affected, but less so than females. These data are interpreted as a systemic effect of ozone on mechanisms of the termination of action of pentobarbital.
||Pub. in Toxicology and Applied Pharmacology 62, 489-497 1982.
|NTIS Title Notes
||Reprint: Effect of Ozone on Drug-Induced Sleeping Time in Mice Pretreated with Mixed-Function Oxidase Inducers and Inhibitors.
|PUB Date Free Form
||21 Oct 81
||PC A02/MF A01