| Main Title |
Benz(j)aceanthrylene: A Novel Polycyclic Aromatic Hydrocarbon with Bacterial Mutagenic Activity. |
| Author |
Sangaiah, R. ;
Gold, A. ;
Toney, G. E. ;
Toney, S. H. ;
Claxton, L. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA-600/J-83-013; |
| Stock Number |
PB83-213918 |
| Additional Subjects |
Mutagens ;
Salmonella ;
Environmental surveys ;
Mutations ;
Aromatic hydrocarbons ;
Bacteria ;
Metabolism ;
Toxicology ;
Reprints ;
Benzaceanthrylene ;
Mutagenesis ;
Dihydroglycol
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-213918 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
Initial studies on the mutagenicity and metabolism of a novel cyclopenta-PAH, benz(j) aceanthrylene, are reported in the Salmonella bacterial system. The spectrum of activity of benz(j)aceanthrylene over the 5 Ames tester strains is similar to that of benzo(a)pyrene, and the dose-response curves for strain TA98 are comparable. Like other biologically active PAH, benz(j)aceanthrylene is a frame-shift mutagen requiring metabolic activation. An interesting feature of the S9 dependence of activity is the low concentration (about 10-fold smaller than for benzo(a)pyrene) at which optimal activity is observed. The 1,2-dihydro-1,2-diol (product of metabolism of the cyclopenta-ring) appears to be the predominant metabolite, and implicates the 1,2-oxide as the ultimate mutagenic species. |
| Availability Notes |
Pub. in Mutation Research 119, p259-266 1983. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Benz(j)aceanthrylene: A Novel Polycyclic Aromatic Hydrocarbon with Bacterial Mutagenic Activity. |
| PUB Date Free Form |
c1983 |
| Category Codes |
6M; 6T; 57K; 57Y; 68 |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
325919038 |
| Origin |
NTIS |
| Type |
CAT |
