| Main Title |
Ninety Day Inhalation Toxicity Study of Hydrogen Chloride Gas in B6C3F1 Mice, Sprague-Dawley Rats and Fisher-344 Rats with Cover Letter dated 05/06/85 and EPA Receipt Letter. |
| CORP Author |
Chemical Industry Inst. of Toxicology, Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
Jun 1985 |
| Year Published |
1985 |
| Report Number |
FYI-OTS-0685-0414-IN; |
| Stock Number |
OTS-0000414-0 |
| Additional Subjects |
Inhalation ;
Toxicity ;
Exposure ;
Mice ;
Rats ;
Procedures ;
Pathology ;
Monitoring ;
Body weight ;
Food consumption ;
Control groups ;
Hydrogen chloride gas ;
B6C3F1 mice ;
Sprague-Dawly rats ;
Fisher-344 rats
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000414-0 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
A 90-day inhalation toxicity study using B (sub 6) C (sub 3) F (sub 1) mice, Sprague-Dawley (CD) rats and Fischer-344 (CDF) rats (exposed simultaneously in the same chambers) was conducted with hydrogen chloride gas. Three groups, each consisting of 31 males and 21 females of each species/strain, were designated as groups T-I, T-II and T-III and exposed to atmospheres of hydrogen chloride as target concentrations of 10 ppm, 20 ppm, and 50 ppm, respectively. After the fourth exposure, 15 males and females per group per species/strain were sacrificed. In addition, a control group (UC) consisting of 31 males and 21 females of each species/strain was exposed to clean air only and was handled in a manner similar to that of the test animals. The duration of exposure was 6 hours per day, 5 days per week for 90 days. Initial exposures for interim sacrifice animals and each species/strain were staggered to accommodate necropsy scheduling. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Category Codes |
57Y |
| NTIS Prices |
PC A02/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010001500 |
| Origin |
NTIS |
| Type |
CAT |
