||Behavioral and Physiological Effects of the Cholinesterase Inhibitor Carbaryl (1-Naphthyl Methylcarbamate).
Sideroff, Stephen I. ;
Santolucito., John A. ;
||Environmental Protection Agency, Perrine, Fla. Primate and Pesticides Effects Lab.
Cholinesterase inhibitors ;
Avoidance responses ;
Sympathetic nervous system ;
Nervous system ;
Laboratory animals ;
Toxic substances ;
||Some EPA libraries have a fiche copy filed under the call number shown.
||The anticholinesterase pesticide carbaryl was injected subcutaneously into rats lever-pressing for liquid reinforcement. During the test session a low intensity footshock accompanied each lever-press response with the carbaryl rats exhibiting a smaller response decrement due to the shock. In the second experiment, carbaryl injected rats displayed a higher behavioral threshold to footshock. These results appear to explain other studies in which animals given anticholinesterase agents show decreased efficiency in performing an avoidance response. Two additional experiments examined the effects of carbaryl on motivation for liquid. Rats lever pressing for liquid reinforcement on an FR-25 schedule were injected with carbaryl. It was found that the response onset after each reinforcement was significantly delayed in the carbaryl animals. This result, in addition to ad lib liquid consumption data, indicated a decreased drive for water in the carbaryl animals. Findings, similar to results obtained using cholinolytics, present an apparent discrepancy which is discussed in terms of (a) the necessity of having an optimum level of Acetylcholine (ACh) in the brain, (b) the possibility of a peripheral mechanism, or (c) the possibility of sympathomimetic effects of carbaryl.
||Pub. in Physiology and Behavior, v9 p459-462 1972.
||Included in the report, Journal Articles on Toxicology. Group 10, PB-280 085.
||Reprint: Behavioral and Physiological Effects of the Cholinesterase Inhibitor Carbaryl (1-Naphthyl Methylcarbamate),
|PUB Date Free Form
||23 Feb 72
||6T; 5J; 92B; 57Y; 68G; 68E; 57R
||(Order as PB-280 085, MF A01)