| Main Title |
Evaluation of the Mutagenicity and Carcinogenicity of Motor Vehicle Emissions in Short-Term Bioassays. |
| Author |
Lewtas, J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA/600/J-83-046; |
| Stock Number |
PB84-101484 |
| Additional Subjects |
Toxicology ;
Exhaust gases ;
Bioassay ;
Evaluation ;
Reprints ;
Mutagenesis ;
Carcinogenesis ;
Automobile exhaust
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-101484 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
Incomplete combustion of fuel in motor vehicles results in the emission of submicron carbonaceous particles which, after cooling and dilution, contain varying quantities of extractable organic constituents. These organics are mutagenic in bacteria. Confirmatory bioassays in mammalian cells provide the capability of detecting chromosomal and DNA damage in addition to gene mutations. In order to evaluate the mutagenicity of these organics in mammalian cells, extractable organics from particle emissions from several diesel and gasoline vehicles were compared in a battery of microbial, mammalian cell and in vivo bioassays. The mammalian cell mutagenicity bioassays were selected to detect gene mutations, DNA damage, and chromosomal effects. Carcinogenesis bioassays conducted included short-term assays for oncogenic transformation and skin tumorigenesis. |
| Supplementary Notes |
Pub. in Environmental Health Perspectives, v47 p141-152 1983. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Evaluation of the Mutagenicity and Carcinogenicity of Motor Vehicle Emissions in Short-Term Bioassays. |
| PUB Date Free Form |
1983 |
| Category Codes |
6T; 6C; 6F; 57Y; 57F; 68A |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
400621332 |
| Origin |
NTIS |
| Type |
CAT |
