| Main Title |
In Vivo Bone Marrow Cytogenetics Study of Santicizer 141 Plasticizer in the Rat HL-83-209(241-151) with Cover Letter and Cover Memo. |
| CORP Author |
Monsanto Co., St. Louis, MO.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1984 |
| Report Number |
878214652 |
| Stock Number |
OTS-0206604 |
| Additional Subjects |
Toxicity ;
Plasticizers ;
Health effects ;
Genotoxicity ;
Chromosomal effects ;
Mammals ;
Rats ;
Laboratory animals ;
Oral ;
Gavage ;
Chromosome abberations ;
Frequencies ;
Dosages ;
2-ethylhexyl diphenyl phosphate ;
Aryl phosphates ;
CAS No 1241-94-7 ;
Bone marrow cells ;
Monsanto Corporation
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0206604 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
70p |
| Abstract |
The frequency of chromosome aberrations was determined in the bone marrow cells of Sprague-Dawley rats exposed by oral gavage to a single dose of 2-ethylhexyl diphenyl phosphate. Forty eight animals per group (24 male and 24 female) received dosages of 0, 1500, 5000 and 15000 mg/kg test article in corn oil. Statistically significant (KW-ANOVA, p < 0.05) differences in the percent aberrant cells, mean number of aberrations per cell, mean mitotic index, or mean modal number were not observed at any dose level. The dose levels were chosen based on the results of a preliminary range finding study and the previously determined LD50. Clinical observations of dose related toxicity during the test included soft feces, urine stains, depression, rough coat, red stains on nose and eyes, hunching and decreased body weights. Additionally, mortality was observed in five animals in the mid dose group. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
6 Aug 1984 |
| Category Codes |
57Y; 57F |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019001740 |
| Origin |
NTIS |
| Type |
CAT |
