| Main Title |
Experimental Pharmacokinetics and Toxicology of Acrylonitrile. |
| CORP Author |
Dortmund Univ. (Germany, F.R.). Inst. fuer Arbeitsphysiologie.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
1984 |
| Year Published |
1984 |
| Report Number |
FYI-OTS-0385-0390-IN; |
| Stock Number |
OTS-0000390-0 |
| Additional Subjects |
Acrylonitrile ;
Pharmacokinetics ;
Toxicology ;
Metabolism ;
Rats ;
Rhesus monkeys ;
Inhalation ;
Toxicity ;
Acute toxicity antidotes
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000390-0 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
52p |
| Abstract |
We noticed a publication about acute acrylonitrile poisoning (case report, Texas Medicine 80, 1984) from the U.S. The authors speculate about N-acetylcysteine as antidote after accidental acrylonitrile poisoning. The toxicity of acrylonitrile may not be attributed to the liberation of cyanide. This is the reason to give you information about our studies. We observed in our experiments only minor cyanide liberation and attribute toxicity of acrylonitrile preferably to cyanoethylation of essential SH-groups. In our acute toxicity studies N-acetylcystein was the most efficient antidote. As a consequence of these works (publications enclosed) some official guidelines in West Germany were changed. You will find a brief summary of these guidelines in the paper 'Clinical Toxicology of Acrylonitrile.' We think N-acetylcysteine is much more effective than cyanide antidotes for therapy of accidental acrylonitrile poisoning on work places in the U.S. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
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| Category Codes |
57Y |
| NTIS Prices |
PC A05/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010001460 |
| Origin |
NTIS |
| Type |
CAT |
