Main Title |
Evaluation of Host Resistance and Immune Function in Cadmium-Exposed Mice (Journal Version). |
Author |
Thomas, P. T. ;
Ratajczak, H. V. ;
Aranyi, C. ;
Gibbons, R. ;
Fenters, J. D. ;
|
CORP Author |
IIT Research Inst., Chicago, IL. Life Sciences Div.;Health Effects Research Lab., Research Triangle Park, NC.;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. |
Publisher |
c1985 |
Year Published |
1985 |
Report Number |
N01-ES-1-5000; EPA/600/J-85/533; |
Stock Number |
PB89-105480 |
Additional Subjects |
Toxicity ;
Cadmium ;
Toxic substances ;
Immunity ;
Immune system ;
Herpes simpley ;
Laboratory animals ;
Exposure ;
Mortality ;
Body weight ;
Disease susceptibility ;
Antibody formation ;
Phagocytosis ;
Natural killer cells ;
Lymphocytes ;
Tissue distribution ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-105480 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
13p |
Abstract |
Adult female B6C3F1 mice received distilled water only or water containing 10, 50, or 250 ppm of cadmium chloride (CdCl2) for 90 days. On Day 91 mice also received a primary challenge with various infectious agents. There was no change in body weight gain, organ weights, or in humoral immunity during treatment even though cadmium had accumulated in significant quantities in the tissues. Compared with controls, exposure to cadmium had no statistically significant effect on mortality and mean survival time following primary or secondary challenge with any of the infectious agents. However, there was a dose-related, increased susceptibility to Herpes simplex type 2 virus. T- and B-lymphocyte proliferation was significantly reduced, and macrophage phagocytosis was significantly increased following cadmium exposure. NK cell activity was augmented, but not significantly. Macrophage bactericidal activity and DTH were not significantly altered. (Copyright (c) 1985 Academic Press, Inc.) |
Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology, v80 p446-456 1985. Sponsored by Health Effects Research Lab., Research Triangle Park, NC., and National Inst. of Environmental Health Sciences, Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Category Codes |
57Y; 57J; 57H; 44G; 68G |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
834421691 |
Origin |
NTIS |
Type |
CAT |