||Lack of Effect of Low Levels of Carboxyhemoglobin on Cardiovascular Function in Patients with Ischemic Heart Disease (Journal Version).
Sheps, D. S. ;
||North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.
Carbon monoxide ;
Angina pectoris ;
Coronary disease ;
Air pollution effects(Human)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Thirty patients 38-75 years of age who had ischemic heart disease were studied to assess the effect of acute elevation of carboxyhemoglobin (COHb) concentration. After an initial familiarization and exercise session patients were exposed to air (carboxyhemoglobin (COHb) = 1.5 + 0.05%) and to carbon monoxide (CO) (100 ppm-CIHb-average = 3.8 + 0.1%) on successive days in a double blind, randomized fashion. There was no significant difference in time to onset of angina (air = 312, CO = 306 sec), maximal exercise time (air = 711 sec, CO = 702 sec) maximal ST depression (1.5 min for both), or time to significant ST depression (air = 474 sec, CO = 475 sec). Double product at ST depression and maximal double products were similar for both conditions. Resting ejection fraction was slightly but nonsignificantly higher after CO exposure (air = 53.9%, CO = 55.2%) Maximal ejection fraction was similar for both conditions (air = 57.4%, CO = 57.1%). Change in ejection fraction was slightly lower for CO exposure (air = 3.5%, CO = 2%), p = .049. In conclusion, there is no clinically significant effect of 3.8% COHb (representing a 2.2% increase from resting values) on the cardiovascular system in the study.
||Pub. in Archives of Environmental Health, v42 p108-116 Mar/Apr 87. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Lack of Effect of Low Levels of Carboxyhemoglobin on Cardiovascular Function in Patients with Ischemic Heart Disease (Journal Version).
||57Y; 57U; 68A; 68G
||PC A03/MF A01