Main Title |
NMDA Antagonist, MK-801, Suppresses Long-Term Potentiation, Kindling, and Kindling-Induced Potentiation in the Perforant Path of the Unanesthetized Rat. |
CORP Author |
Northrop Services, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1990 |
Year Published |
1990 |
Report Number |
EPA/600/J-90/170; |
Stock Number |
PB91-116087 |
Additional Subjects |
Pharmacology ;
Evoked potentials ;
Amygdala ;
Synapses ;
Reprints ;
MD-801 ;
Kindling(Neurology) ;
N-methyl-d-aspartate ;
Long-term potentiation ;
Drug antagonism
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-116087 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Antagonism of NMDA-mediated transmission by MK-801 has been shown to block long-term potentiation (LTP) in vitro and delay electrical kindling of the amygdala. The experiment sought to examine the relationship between synaptic potentiation of the perforant path-granule cell synapse and development of perforant path kindling. MK-801 (0.1 and 1.0 mg/kg) blocked induction of LTP of the perforant path in the unanesthetized animal measured 24 h after train delivery. The 1.0 mg/kg dosage also increased afterdischarge (AD) thresholds, delayed kindling development from daily stimulation of the perforant path (x = 8.82 + or - and 22.9 + or - 3.66 sessions to the first stage 5 seizure), and increased AD durations. Kindling produced a significant potentiation of the EPSP (47%) and population spike (49%) after the first evoked AD in control animals. No significant enhancement of either component of the field potential was observed in MD-801-treated animals. Animals treated with this dosage of MD-801, did, however, kindle in the absence of potentiation at this synapse. It was concluded that although NMDA-mediated potentiation may facilitate kindling, synaptic potentiation does not appear to be a critical requirement for kindling to develop. (Copyright (c) 1990 Elsevier Science Publishers B.V.) |
Supplementary Notes |
Pub. in Brain Research, v519 n1-2 p89-96, 11 Jun 90. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: NMDA Antagonist, MK-801, Suppresses Long-Term Potentiation, Kindling, and Kindling-Induced Potentiation in the Perforant Path of the Unanesthetized Rat. |
Category Codes |
57Q; 57S |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
101123393 |
Origin |
NTIS |
Type |
CAT |