| Main Title |
Interspecies Comparisons of A/D Ratios: A/D Ratios Are Not Constant Across Species. |
| Author |
Daston, G. P. ;
Rogers, J. M. ;
Versteeg, D. J. ;
Sabourin, T. D. ;
Baines, D. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. ;Procter and Gamble Co., Cincinnati, OH. Human and Environmental Safety Div. ;Battelle, Columbus, OH. |
| Publisher |
c1991 |
| Year Published |
1991 |
| Report Number |
EPA/600/J-92/024; |
| Stock Number |
PB92-143965 |
| Additional Subjects |
Toxicity ;
Teratogens ;
Species specificity ;
Invertebrates ;
Laboratory animals ;
Lethal dosage ;
Toxic substances ;
Tables(Data) ;
Amphibia ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-143965 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
29p |
| Abstract |
The hypothesis that the ratio of the adult (A) and developmental (D) toxicity of a chemical is constant across animal species has been proposed as the basis for identifying developmental hazards, both from traditional developmental toxicity screens using laboratory mammals and from alternative systems such as the coelenterate Hydra attenuata. The purpose of the study was to determine whether A/D ratios are constant across species. The developmental and adult toxicity of 14 chemicals was assessed in four phylogenetically different species. The chemicals tested were aminopterin, bromodeoxyuridine, cadmium chloride, caffeine, congo red, dinocap, dinoseb, diphenylhydantoin, epinephrine, ethylenethiourea, 2-methoxyethanol, mirex, all-trans-retinoic acid, and trypan blue. Data indicate that A/D ratios are not constant across these representative species, and there is no basis for using A/D for hazard assessment. |
| Supplementary Notes |
Pub. in Fundamental and Applied Toxicology, v17 n4 p696-722 Nov 91. Prepared in cooperation with Procter and Gamble Co., Cincinnati, OH. Human and Environmental Safety Div., and Battelle, Columbus, OH. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Interspecies Comparisons of A/D Ratios: A/D Ratios Are Not Constant Across Species. |
| Category Codes |
57Y; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
208728769 |
| Origin |
NTIS |
| Type |
CAT |
