| Main Title |
Embryo-Fetal Toxicity and Teratogenic Potential of Ammonium Perfluorooctanoate (APFO) in the Rat with Publisher Receipt Letter dated 08/08/83 and Dupont Cover Letter dated 08/19/83. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Wilmington, DE.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
19 Aug 1983 |
| Year Published |
1983 |
| Report Number |
FYI-OTS-0983-0264-IN; |
| Stock Number |
OTS-0000264-0 |
| Additional Subjects |
Toxicity ;
Rats ;
Inhalation ;
Testing ;
Ammonium perfluorooctanoate ;
Embryo-fetal toxicity ;
Teratogenic potential ;
Sprague Dawley rats
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000264-0 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
56p |
| Abstract |
APFO (> 95% pure) was administered to Sprague Dawley rats from Days 6 through 15 of gestation of inhalation as a dust (whole body exposure) for 6 hr/day at 0, 0.1, 10, and 25 mg/m (sub 3), or by gavage at 100 my/kg body weight/day in corn oil. Maternal deaths occurred in the groups given the highest level of APFO by each route and overt toxicity was evident among the surviving dams of these groups and among those of the 10 mg/m (sub 3) group. The fetuses were examined for external, visceral, and skeletal alterations and for APFO-related macroscopic and microscopic alterations of the eyes. In the postpartum period, pups from additional control and experimental dams were examined externally and ophthalmoscopically, and the usual fertility and viability indices were calculated. A teratogenic response was not demonstrated. Toxic effects on the conceptus were noted only in the groups given the highest level of APFO by each route. Hence, APFO was not demonstrated to represent a unique hazard to the conceptus of the rat. |
| Supplementary Notes |
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| Availability Notes |
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| Category Codes |
57Y |
| NTIS Prices |
PC A05/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010000260 |
| Origin |
NTIS |
| Type |
CAT |
