Main Title |
Increased Hippocampal Excitability Produced by Amitraz (Journal Version). |
Author |
Gilbert, M. E. ;
Dyer, R. S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
Publisher |
c1988 |
Year Published |
1988 |
Report Number |
EPA/600/J-88/158; |
Stock Number |
PB89-110555 |
Additional Subjects |
Toxicology ;
Pesticides ;
Hippocampus ;
Central nervous system ;
Neural transmission ;
Evoked potentials ;
Laboratory animals ;
Reprints ;
Amitraz ;
Toxic substances ;
Methanimidamide/N'-dimethyphenyl-N-dimethyphenyl-iminomethyl-N-methyl
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-110555 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
The study characterized the effect of the formamidine pesticide, amitraz, upon hippocampal function in male Long Evans rats. Animals were chronically prepared with a stimulating electrode in the perforant path and field potentials were recorded from a bipolar electrode situated across the granule cell layer of the dentate gyrus. Input/output functions and paired pulse inhibition were monitored in unrestrained, unanesthetized animals over a number of days following acute administration of 100 mg kg of amitraz. Inout/output functions revealed a decrease in excitatory postsynaptic potential (EPSP) slope and an increase in population spike height 4 and 24 hr after treatment, with return to baseline by 48 hr. Tests of inhibition using pairs of stimulus pulses delivered at intervals ranging between 20 and 100 msec revealed a decrease in inhibition following amitraz. Both of these effects could be mimicked by administration of 0.1 mg/kg of the alpha-2 agonist clonidine, supporting this mode of action of amitraz on CNS function. The results indicate that systemic amitraz treatment produced a transient enhancement of excitatory and reduction of inhibitory processes in a CNS pathway. |
Supplementary Notes |
Pub. in Neurotoxicology and Teratology, v10 p229-235 1988. Prepared in cooperation with Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Increased Hippocampal Excitability Produced by Amitraz (Journal Version), |
Category Codes |
68E; 68G; 57H; 57Y |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
834424965 |
Origin |
NTIS |
Type |
CAT |