| Main Title |
Mode of action of cyclodiene insecticides : the nervous system influenced by toxaphene / |
| Author |
Crowder, Larry A.
|
| Other Authors |
|
| Publisher |
Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, |
| Year Published |
1980 |
| Report Number |
EPA-600/1-80-003; EPA-R-804351 |
| Stock Number |
PB80-186042 |
| OCLC Number |
07558297 |
| Subjects |
Amidines ;
Insecticides ;
Toxaphene
|
| Additional Subjects |
Insecticides ;
Toxicology ;
Pesticides ;
Terpenes ;
Chlorine aliphatic compounds ;
Chlorohydrocarbons ;
Halohydrocarbons ;
Nervous system ;
Metabolism ;
Excretion ;
Rats ;
Insects ;
Laboratory animals ;
Experimental data ;
Physiological effects ;
Toxaphene
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-80-003 |
|
Headquarters Library/Washington,DC |
04/23/2014 |
| EJED |
EPA-600/1-80-003 |
|
OCSPP Chemical Library/Washington,DC |
01/01/1988 |
| EKCD |
EPA-600/1-80-003 |
|
CEMM/GEMMD Library/Gulf Breeze,FL |
05/29/2018 |
| ELBD ARCHIVE |
EPA 600-1-80-003 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| NTIS |
PB80-186042 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
xv, 93 pages : illustrations ; 28 cm. |
| Abstract |
A study was made concerning the mode of action, excretion, metabolism, and behavioral effects of toxaphene and combinations of toxaphene, methyl parathion, and/or chlordimeform in various insects, the mouse and rat. Toxaphene (1) altered ionic movements within the central nervous system of the cockroach, Periplaneta americana, (2) increased levels of cAMP and cGMP in tissues of the cockroach, Leucophaea maderae, and the mouse, and (3) inhibited ATPase enzymes in tissues of P. americana and the mouse. Rat pups perinatally exposed to sublethal doses of toxaphene and methyl parathion showed few significant changes in motor skills, behavior, or learning ability. Postnatal exposure to toxaphene did lead to an impairment of learning ability in adult rats as measured by a simple T-maze. Combining chlordimeform and methyl parathion with 36Cl recovered in feces and the amount deposited in tissues of orally-dosed mice. Combining toxaphene with methyl parathion did not potentiate the toxicity of methyl parathion under laboratory conditions to various hemipteran predators and lepidopterous pests. |
| Notes |
"January 1980"--Cover. "Project no. R-804351." "Project officer, Robert Lewis." Includes bibliographical references. |
| Place Published |
Washington, D.C. |
| Supplementary Notes |
See also PB-251 670. |
| Corporate Au Added Ent |
Health Effects Research Laboratory (Research Triangle Park, N.C.) |
| Title Ser Add Ent |
Research reporting series. Environmental health effects research ; EPA-600/1-80-003. |
| PUB Date Free Form |
1980 |
| Series Title Traced |
Research reporting series Environmental health effects research series EPA-600/1-80-003 |
| Series Title Untraced |
Research reporting series. 1, Environmental health effects research ; EPA-600/1-80-003 |
| NTIS Prices |
PC A06/MF A01 |
| BIB Level |
m |
| Document Type |
BC |
| Medium |
unmediated |
| Content |
text |
| Carrier |
volume |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20180523083009 |
| Language |
eng |
| SUDOCS Number |
EP 1.23/4:600/1-80-003 |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
02153cam 2200565Ia 45010 |
