Main Title |
Initial Submission: Letter from Confidential Source to USEPA Reporting Preliminary Neurotoxic Results in Acute Inhalation Toxicity Study in Rats of (Confidential), an Alkynyl Chloride, dated 12/15/1999. (Sanitized). |
CORP Author |
; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1999 |
Report Number |
8EHQ-1299-14617S |
Stock Number |
OTS0559864 |
Additional Subjects |
Inhalation ;
Toxicity ;
Rats ;
Vapors ;
Toxic substance ;
Neurotoxicity ;
Males ;
Females ;
Dosage ;
Mortality ;
Exposure ;
Death ;
Tremors ;
Laboratory animals ;
Alkynyl chloride
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0559864 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
Clinical signs indicative of neurotoxicity (i.e., ataxia, fasciculations, prostration, salivation, lacrimation, trmors, abnormal gait, sensitivity to touch, and/or dragging/splayed hind limbs) were discovered among survivors and decedents at 898 ppm (5 of 6 males; 6 of 6 females) and 1677 ppm (6 of 6 males; 6 of 6 females). these signs were noted beginning removal from the chamber and continued through day 12. No clinical signs of neurotoxicity were noted at 312 ppm in either sex. Dose related mortality occurred in this study (0/6 males and 0/6 females at 312 ppm; 4/6 males and 2/6 females at 898 ppm; and 5/6 males and 6/6 females at 1677 ppm). All deaths occurred by day 7 post-exposure. |
Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
PUB Date Free Form |
15 Dec 1999 |
Category Codes |
57Y; 57U; 68G; 99 |
NTIS Prices |
PC A02/MF A02 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
010500920 |
Origin |
NTIS |
Type |
CAT |