| Main Title |
Initial Submission: Pilot Teratology Study with Decyl Alcohol in Rabbits with Cover Letter dated 08/04/92 and Attachment. |
| CORP Author |
International Research and Development Corp., Mattawan, MI.; Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920004887 |
| Stock Number |
OTS0540964 |
| Additional Subjects |
Toxicology ;
Health effects ;
Decyl Alcohol ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rabbits ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 26183-52-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0540964 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
29p |
| Abstract |
Ethoxylated Decyl Alcohol (CAS No. 26183-52-8) was evaluated to determine the dosage levels for a teratology study. Groups of 5 female New Zealand white rabbits were administered the test substance by gavage at dose levels of 0, 0.12, 0.25, 0.50, 0.75 and 1.00 g/kg/day for 13 days. Mortalities included 1 at 0.12 g/kg, 5 at 0.25 g/kg, 4 at 0.50 g/kg, 4 at 0.75 g/kg, and 5 at 1.00 g/kg. Sixteen of 19 deaths were due to respiratory distress, 2 were due to dosing error (1 each at 0.12 and 0.25 g/kg), and 1 death at 0.75 was due to gastritis. Clonic convulsion were observed at all dose levels (convulsions were more frequent at higher dose levels). Rabbits at 0.50, 0.75 and 1.00 g/kg/day groups displayed tonic convulsions and respiratory distress. There was slight weight loss at 0.50 g/kg/day, moderate weight loss at 0.25, 0.50, and 0.75 g/kg/day, and severe weight loss at 1.00 g/kg/day. Food consumption was statistically decreased at 0.12, 0.25, 0.50, and 0.75 g/kg/day throughout the treatment period and at 1.00 g/kg/day prior to death. The level of significance in all cases was p<0.05. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803550 |
| Origin |
NTIS |
| Type |
CAT |
