| Main Title |
Effect of Phenylethyl Alcohol (pea) on Pregnancy of the Rat with Cover Letter Dated 04/18/1986. |
| CORP Author |
Huntingdon Research Centre PLC (England).; Cosmetic, Toiletry and Fragrance Association, Inc., Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1986 |
| Report Number |
89-8680232 |
| Stock Number |
OTS0509772-1 |
| Additional Subjects |
Toxicology ;
Health effects ;
Phenylethyl Alcohol ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 60-12-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0509772-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
80p |
| Abstract |
The effects of phenylethyl alcohol (PEA) on the pregnancy of female CrL: COBS CD (SD) BR strain rats (25/control and mid-dose groups, 35/low- and high-dose groups) exposed to PEA by skin painting at dose levels of 0 (water control), 0.14, 0.43 or 1.40 ml/kg/day during days 6-15 of pregnancy were evaluated. The animals were sacrificed on day 20 of pregnancy. Significant differences between high-dose level and control dams were observed in the following: increased clinical observations such as irritability, hunched posture, walking on toes, piloerection and peri-orbital staining, and increased mortality (3/35 animals), decreased body weight gain, decreased levels of creatinine, glutamic-pyruvic transaminase, and increased white cell count. Significant differences between high-dose level and control litter parameters were observed in the following: increased incidence of embryo-fetal deaths (primarily early in pregnancy), decrease in litter size and weight, increased incidence of defects including anophthalmia/microphthalmia, ventricular septal defects, defects/irregularities affecting thorax, and/or kinky tail, defects of the thoracic ribs and occurrence of cervical rib(s). No significant differences between treated and control animals were observed in the following: relative liver and kidney weights, or pregnancy rates. No significant differences between mid- and low-dose level and control groups were observed with respect to maternal toxicity or litter parameters, although a small, dose-dependent increase in some of the morphological parameters was observed in the fetuses of the mid-dose level group. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Cosmetic, Toiletry and Fragrance Association, Inc., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A06/MF A06 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801340 |
| Origin |
NTIS |
| Type |
CAT |
