| Main Title |
Acute Vapor Inhalation Toxicity Study in Rats with Cover Letter. |
| CORP Author |
Industrial Bio-Test Labs., Inc., Northbrook, IL. ;Occidental Chemical Corp., Niagara Falls, NY.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
27 Jan 1983 |
| Year Published |
1983 |
| Report Number |
878212097; |
| Stock Number |
OTS-0205956 |
| Additional Subjects |
Vapors ;
Inhalation ;
Toxicity ;
Rats ;
Necropsies ;
Exposure ;
Death ;
Body weight ;
Mortality ;
Pathology ;
Pneumonia ;
Consolidation ;
Inflammatory diseases ;
Lungs ;
Air pressure ;
Air flow ;
Laboratory animals ;
Testing ;
Hexachlorocyclopentadiene ;
Occidental Chemical Corporation
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0205956 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
373p |
| Abstract |
Complete necropsies were done on all surviving rats on termination of the study. Similar examinations were done as quickly after death as possible on rats that died during the experiment. Three male rats and one female rat in test group I, four male rats and two female rats in test group II, five male rats and four female rats in test group III and all rats in test group IV died during the experiment. Acute pneumonia characterized by varying degrees of consolidation (Hepatization) was observed in rats that died shortly after exposure to the test material. Treated rats that survived to completion of the study were described as emaciated. Frequently, the lungs of these animals did not collapse when the thorax was opened. This suggests a chronic proliferative inflammatory response in the lungs of affected animals. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Category Codes |
57Y; 57O; 68A |
| NTIS Prices |
PC A17/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
009400900 |
| Origin |
NTIS |
| Type |
CAT |
