| Main Title |
Acute Oral Administration of Benzotriazole to Rats with Cover Letter Dated 06/12/1989. |
| CORP Author |
Sherwin-Williams Co., Chicago, IL.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1989 |
| Report Number |
86-890000592 |
| Stock Number |
OTS0520631 |
| Additional Subjects |
Toxicology ;
Health effects ;
Benzatriazole (95-14-7) ;
Acute Toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 95-14-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0520631 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Acute oral toxicity was evaluated in groups of 5 male albino Greenacres rats administered, by gavage, benzotriazole at dose levels of 46.4, 100 and 215 mg/kg in a 10% (w/v) suspension, or 464, 1000 and 2150 mg/kg in a 50% suspension. Mortality was observed within 14 days of dosing (4 rats each in the 1000 and 2150 mg/kg). No mortalities were observed at any dose level of the 10% suspension. The oral LD50 was 909 mg/kg (95% confidence limit = 546 to 1510 mg/kg). Clinical observations included depressed righting and placement reflexes among animals of the 46.4, 100 and 215 mg/kg dose groups. At high dose levels, observations included depressed righting and placement reflexes, absence of pain, shallow respiration, followed by death. Gross necropsy revealed paled extremities, slight to moderate congestion of lungs, kidneys and adrenals, and slight irritation of the small intestines. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1989 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028807820 |
| Origin |
NTIS |
| Type |
CAT |
