| Main Title |
Acute Inhalation Toxicity in Rats Using Dibutylamine: Four Hour Exposure. |
| CORP Author |
Huntingdon Research Centre PLC (England).; Pennwalt Corp., King of Prussia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
86-870000540 |
| Stock Number |
OTS0513618 |
| Additional Subjects |
Toxicology ;
Health effects ;
Dibutylamine (111-92-2) ;
Acute Toxicity ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 111-92-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0513618 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
42p |
| Abstract |
Acute inhalation toxicity was evaluated in groups of 5 male and 5 female Sprague-Dawley albino rats exposed to dibutylamine at actual concentrations of 0.76, 1.08, 1.18, 1.39 or 3.91 mg/l of air for 4 hours. Mortality was observed in 2 animals in the 0.76 mg/l dose group, 4 in the 1.18 mg/l dose group, and all 10 in both the 1.39 and 3.91 mg/l dose groups. The LC50 value was calculated to be 1.15 mg/l (standard error of 0.095 mg/l) by the log probit method of Miller and Tainter. Clinical observations included excessive salivation, lacrimation, gasping, convulsions, abnormal breathing, ataxia, lethargy, rales, and staining of the urogenital area. Gross necropsy revealed lung congestion in decedents. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Pennwalt Corp., King of Prussia, PA. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801810 |
| Origin |
NTIS |
| Type |
CAT |
