| Main Title |
Approximate Lethal Dose of Hfc-152a in Rats with Cover Letter (Sanitized). |
| CORP Author |
; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1990 |
| Report Number |
86-910000029S |
| Stock Number |
OTS0530083 |
| Additional Subjects |
Toxicology ;
Health effects ;
1 ;
1-difluoroethane (75-37-6) ;
Acute Toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 75-37-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0530083 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
1,1-Difluoroethane (75-37-6) was evaluated for acute oral toxicity in 6 male Crl: CD BR rats administered doses of 200, 300, 450, 670, 1000, and 1500 mg/kg of by gavage. The use of controls was not specified. The observation period was 14 days post-treatment. No mortalities occurred. Clinical signs immediately after dosing in all rats included abdominal distension and lethargy. Clinical signs seen with 48 hours post-dosing included high carriage, wet and yellow stained perineums and diarrhea. Necropsy and a histopathological examination were not specified. The LD50 for 1,1-difluoroethane is greater than 1500 mg/kg, and was considered to be slightly toxic when administered as a single oral dose in rats. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1990 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803110 |
| Origin |
NTIS |
| Type |
CAT |
