| Main Title |
Acute Toxicity of N-isopropylaniline Administered by Inhalation to Sprague-dawley Male and Female Rats with Cover Letter dated 05/06/94. |
| CORP Author |
Monsanto Co., St. Louis, MO.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.; Dow Corning Corp., Midland, MI. |
| Year Published |
1994 |
| Report Number |
8EHQ-86940000409 |
| Stock Number |
OTS0572512 |
| Additional Subjects |
Toxicology ;
Health effects ;
N-Isopropylaniline ;
Toxicity ;
Acute toxicity ;
Mammals ;
Rats ;
Inhalation ;
CAS No 768-52-5 ;
Toxic substances ;
Laboratory animals
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0572512 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
54p |
| Abstract |
N-isopropylaniline (CAS No. 768-52-5) was evaluated for acute inhalation toxicity in groups of Sprague-Dawley rats (5/sex/group) exposed for 4 hours in an inhalation chamber to mean analytical concentrations of 1.4, 1.4, 1.3, 1.0 mg/L vapor/aerosol in air. Mortality associated with treatment was consistent with an LC50 (probit) of 1.2 mg/L in air. Rats of a 1.0 mg/L exposure showed neither overt signs of toxicity nor diminished weight gain, while all other treated groups exhibited a transient decrease in mean bodyweights on Day 2 following exposures. Hypoactivity and respiratory distress or irritation were the most oft reported clinical irregularities during 14-day post-exposure observation. Necropsy of both surviving and decedent rats revealed no treatment-related pathology. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028804080 |
| Origin |
NTIS |
| Type |
CAT |
