| Main Title |
Initial Submission: Acute Oral Toxicity of Thiols, C8-20, Gamma-Omega-Perfluoro, Telomers with Acrylamide in Rats with Cover Letter dated 08/28/1992. |
| CORP Author |
CIBA-GEIGY Corp., Ardsley, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
EPA-OTS-88-920009487 |
| Stock Number |
OTS0571143 |
| Additional Subjects |
Toxicology ;
Health effects ;
Thiols ;
Gamma-omega-perfluoro ;
Telomers w/acrylamide ;
Gavage ;
Mammals ;
Rats ;
Oral ;
CAS No 70969-47-0
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571143 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
33p |
| Abstract |
Four male and two female rats died at the initial 5.0 g/kg oral dose, making it necessary to do an LD50 screen. The dose levels determined from the screen results were 2.5, 3.3, 4.2 and 5.0 g/kg. Deaths occurred at all levels except for the 2.5 g/kg level. Deaths occurred generally by Day 4 with predeath toxic signs of lethargy, chromorhinorrhea, chromodacryorrhea, emaciation, piloerection,body surfaces stained brown, ptosis, ataxia, diarrhea, tremors, tachypnea and prostration. Necropsy of the spontaneous deaths revealed lung and gastro- intestinal abnormalities. Toxic signs, seen in the survivors, included lethargy, chromorhinorrhea, piloerection, ptosis, chromodacryorrhea, ataxia, diarrhea, flaccid muscle tone, body surfaces stained brown and hyperactivity. All animals were generally normal from Day 9 to Day 14. Body weight changes of the Survivors were normal. Recropsy was normal in most survivors. However, a few had liver or kidney abnormalities. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
28 Aug 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
018801580 |
| Origin |
NTIS |
| Type |
CAT |
