| Main Title |
Drosophila Sex-linked Recessive Assay of Acrylamide -with Co ver Letter 12/10/1985. |
| CORP Author |
Microbiological Associates, Bethesda, MD.; American Cyanamid Co., Wayne, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1985 |
| Report Number |
878216232 |
| Stock Number |
OTS0206897 |
| Additional Subjects |
Toxicology ;
Health effects ;
Acrylamide (79-06-1) ;
Genotoxicity ;
Gene Mutations ;
Insects ;
Oral ;
Diet ;
Toxic substances ;
Laboratory animals ;
CAS No 79-06-1
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0206897 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
18p |
| Abstract |
The ability of acrylamide to induce sex-linked recessive lethal mutations in post-meiotic germ cells was evaluated in Drosophila melanogaster males (Canton-S wild type stock). Acrylamide was highly toxic at 2500 ppm and above in initial tests and treatment of 100 ppm induced significant sterility. Based on preliminary toxicity and sterility observations, 8-30 hour old males (15/group) were fed acrylamide at concentrations of 25, 50, and 100 ppm for 1 day (sterilization occurred with a 72-hour exposure) and then mated at 3-4 days old to 3 virgin 'Basc' females (3-10 days old). After 3 days, males were transferred to sets of 3 new virgin females for 2 days each. No male mortality was observed during treatment, however, 5% male mortality was observed during brooding. Male sterility observed was 0, 29, and 21% for broods 1, 2, and 3 respectively. Acrylamide did not cause a statistically significant increase in the number of lethals relative to the negative controls (sucrose/distilled water). |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Cyanamid Co., Wayne, NJ. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1985 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801120 |
| Origin |
NTIS |
| Type |
CAT |
