| Main Title |
Initial Submission: Letter from Dupont Chemical to USEPA regarding Toxicity Studies of Acrolein with Cover Letter dated 10/15/1992. |
| CORP Author |
Union Carbide Corp., Danbury, CT.; Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-1092-11540 |
| Stock Number |
OTS0571470 |
| Additional Subjects |
Toxicology ;
Health effects ;
Acrolein ;
Acute toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Rabbits ;
Dermal ;
Inhalation ;
Primary dermal irritation ;
Primary eye irritation ;
CAS No 107-02-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571470 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
In both studies, beagle dogs were administered dietary concentrations of 2,000, 5,000 or 20,000 ppm. Those dogs administered the test material encapsulated in silica were found to exhibit reduced hemoglobin and hematocrit values, as well as abnormal erythroyote morphology. Histopathology revealed dose-related renal lesions. Chromium and lead levels were elevated in the liver, kidneys, bone and brain. In the other study, treatment-related effects also included a decrease in henoglobin and hematocrit values, as well as abnormal erythrocyte morphology. Histopathology revealed focal tubular nephrosis. Microscopic examination of brain and spinal cord revealed characteristic, lead-induced lesions in 4 of 8 dogs at the 20,000 ppm dose level. The content and chromium of the liver, kidney, and brain tissue were increased in all dogs. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
27 Oct 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028700120 |
| Origin |
NTIS |
| Type |
CAT |
