| Main Title |
Cutaneous Carcinogenicity Study with Mice on the Diglycidyl Ether of 1,4-butane Diol with Attachments and Cover Letter dated 09/28/1987. |
| CORP Author |
CIBA-GEIGY Corp., Ardsley, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1987 |
| Report Number |
86-880000066 |
| Stock Number |
OTS0513957 |
| Additional Subjects |
Toxicology ;
Health effects ;
1 ;
4-butane Diol (2425-79-8) ;
Chronic Toxicity ;
Carcinogenicity ;
Mammals ;
Mice ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 2425-79-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0513957 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
53p |
| Abstract |
Dermal carcinogenicity was evaluated in groups of male and female CF1 mice (50/sex/group) receiving applications (volume not reported) of 0.05% or 0.2% (based on preliminary studies) 1,4-butanediol diglycidyl ether in acetone twice weekly to the dorsal skin for 103 weeks. Of all animals in both dose groups, 5 animals developed 6 neoplasms of the skin and subcutis; 1 control animal developed a tumor. A transient irritant reaction was observed in 37 animals with no thickening of the epidermis. A statistically significant increase in neoplasms of the treated skin was not observed. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1987 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801850 |
| Origin |
NTIS |
| Type |
CAT |
