Main Title |
2 Phenoxyethanol: Two-week Dermal Probe Study in Female New Zealand White Rabbits to Assess Hematological Effects with Cover Letter. |
CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1985 |
Report Number |
878216053 |
Stock Number |
OTS0206805 |
Additional Subjects |
Toxicology ;
Health effects ;
2-phenoxyethanol (122-99-6) ;
Subchronic Toxicity ;
Mammals ;
Rabbits ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 122-99-6
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0206805 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
22p |
Abstract |
Subchronic toxicity was evaluated in groups of 10 female New Zealand White rabbits exposed to 2-phenoxyethanol for 14 consecutive days at a level of 0 or 0.91 ml/kg/day as an occluded dose to clipped, intact skin. Mortality was observed in 7 rabbits by day 8 of the experiment. Clinical observations included discoloration of the skin at the test site. Necropsy revealed hemoglobinuria; pale livers; dark kidneys and spleens; decreased hemoglobin, PCV and RBC values; increased erythrocyte indices, nucleated RBC's, leukocytes and erythrocytes; and regenerative hemolytic anemia due to intravascular hemolysis of RBC's. |
Supplementary Notes |
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Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
PUB Date Free Form |
1985 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A03/MF A03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028801100 |
Origin |
NTIS |
Type |
CAT |