| Main Title |
Letter from Chemical Manufacturers Association to US EPA Submitting Enclosed Final and Interim Reports on 2-ethylhexanoic Acid with Attachments. |
| CORP Author |
Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8797187 |
| Stock Number |
OTS0525556 |
| Additional Subjects |
Toxicology ;
Health effects ;
2-ethylhexanoic Acid ;
Acute Toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Primary Dermal Irritation ;
Dermal ;
Pharmaco Kinetics ;
Subchronic Toxicity ;
Mice ;
Toxic substances ;
Laboratory animals ;
CAS No 149-57-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0525556 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
54p |
| Abstract |
2-Ethylhexanoic acid (EHA) was evaluated for acute toxicity to female Fischer F-344 rats (4/group) exposed to single oral doses of 0, 100, 800, 1600, or 3200 mg/kg of EHA administered in corn oil by gavage. Animals were observed for 14 days prior to necropsy. Mortality (4/4) occurred within 24 hours at the high- dose. Transitory weakness was observed in lower-dose animals. The acute oral LD50 for rats was 2043 (1445 to 2890) mg/kg. Preliminary data summaries of the following studies are presented: 1) A dermal irritation test with female rats exposed for 96 hours to 1 g/kg of undiluted EHA under occlusion; serious damage was seen in epidermal tissues within 24 hours. 2) Pharmacokinetic studies with rats orally exposed to 0.1 or 1.0 g/kg by gavage; urinary excretion accounted for 80% of each dose by 96 hours post- treatment, while fecal excretion accounted for about 12% of the low dose and 6% of the high-dose. Several metabolites were separated, but not identified. 3) 14-Day oral toxicity probe studies with mice and rats exposed to 0, 200, 800, or 1600 mg/kg/day EHA by gavage; 1600 mg/kg/day was lethal to rats, and 800 mg/kg/day led to decreased weight gain in males and increased liver weights in both sexes. In mice, there were slight changes in liver weights of high-dose animals. The NOAEL for mice was 800 mg/kg/day, and for rats, 200 mg/kg/day. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802680 |
| Origin |
NTIS |
| Type |
CAT |
